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Policy-bounded simulation for treatment planning research

Translational Oncology

We explore agent-based simulations that model treatment responses under real-world constraints. Powered by SVM-OS, these studies aim to help teams reason about options, trade-offs, and risk - with audit trails for every step. 

Find out more

Problem → Why now

 Oncologists and researchers face complex, evolving combinations of therapies, dosing schedules, and patient contexts. Real trials are slow and costly; purely retrospective analytics can miss policy and safety constraints that matter in practice. 

Our approach (conceptual only)

sandboxed SVMs encode perception, memory, and policy-aware decision logic. 


experiments run under explicit constraints (eligibility, sequencing, dose limits, timing windows). 


kernel guarantees (deterministic ticks, capability enforcement, append-only logs) enable reproducible runs and review. 


agents communicate via substrate primitives ( substrate-native message and execution primitives (details under NDA) with logged events for traceability. 


Translational Oncology - At a glance

What “good” looks like (targets)

What “good” looks like (targets)

What “good” looks like (targets)

  • Explainable scenarios — why a simulated plan improved or degraded under constraints.
     
  • Comparative planning — side-by-side runs to explore trade-offs.
     
  • Operational realism — simulations respect policies and safety constraints.
     
  • Provenance — each result is backed by replayable event logs.

Safeguards & scope

What “good” looks like (targets)

What “good” looks like (targets)

  • Not a medical device. Outputs are research tools to inform exploration, not to direct care.
     
  • Human-in-the-loop by design: clinicians/researchers control inclusion criteria, constraints, and interpretation.
     
  • Data handling aligns to customer governance; we practice data minimization and permissioned execution.


Detailed controls available under NDA.

Status

What “good” looks like (targets)

Status

  • Prototype studies in development with internal reviewers.
     
  • Seeking design partners (academic/clinical/industry) for scoped pilots.

Frequently Asked Questions

No. It’s a research and planning aid with policy constraints and full auditability. 


Yes, under customer governance with permissioned interfaces. We favor minimal, purpose-bound inputs. 


 A defined question, policies/constraints to apply, and a governed environment. Technical brief under NDA. 


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are trademarks of Substrate AI LLC.  

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